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In This Issue

Director's Message:

Support VSI

Vitiligo Coping Mechanisms:
What is Your Attachment Style?

Camp Discovery 2017

Medicare Coverage for
Vitiligo Treatments

What's On Your Mind?

  • I’ve been using a topical for 3
    months and now I am losing
    more pigment. What should I do?

  • How long should I continue treating
    an area after it is repigmented?

Medical News Updates

  • Testing to Predict Vitiligo!

  • Drug Shows Promise for Vitiligo:
    Clinical Trial to Begin Recruiting

Research & Clinical Trials

Bibliography & Sources

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View Past Newsletters

VSI Medical and Scientific
Advisory Committee

  • Pearl E. Grimes, M.D., Committee Chair
  • Ted A. Grossbart, Ph.D.
  • Sancy A. Leachman, M.D.
  • I. Caroline Le Poole Ph.D.
  • Mauro Picardo, M.D.
  • Nanette B. Silverberg, M.D.
  • Richard A. Spritz, M.D.
  • Alain Taieb, M.D., Ph.D.
  • Wiete Westerhof, MD, Ph.D.

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Contact Us


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Vitiligo Support International
P.O. Box 3565
Lynchburg Va 24503

(434) 326-5380

Message From the Executive Director

VSIDear Members and Friends of VSI,

VSISpring is a time of hope, change, and new beginnings. Spring cleaning can help get rid of the clutter in your home and make room for things fresh and new. Why not also make spring a time to evaluate the inventory of your emotional house? Don’t be afraid to look into the baggage and dark corners. Throw away the dusty, negative thoughts that are weighing you down, and open the door to positive energy!

Our article in this issue focuses on recognizing the problems and impediments to a happier life, and learning about modifications you can make to bring positive change. We all have obstacles and problems in our lives, but, as Condoleezza Rice once said:

“You may not be able to control your circumstances,
but you can control your response to your circumstances.”

We hope that after reading the article below you will be inspired to take stock of your emotional baggage and give thought to changes you can make to prepare for a more positive and healthy future.

Jackie Gardner
Executive Director


This organization is a Silver-level GuideStar Exchange
participant, demonstrating its commitment to transparency.

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We’d like to take this opportunity to extend our most heartfelt gratitude
to each and every VSI Supporting Member and Donor.

As a nonprofit organization, all of VSI’s efforts: publications, programs, services, professional meetings and memberships, our office (staffed 5 days a week), server space, website, IT programmers, newsletter software, and much more, is sustained by the generous support of our donors.

If each person reading this newsletter made an annual donation
of just $10.00, VSI could nearly double its 2017 income.

Every Dollar Counts!

Will You Support VSI’s Campaign to Transform the Future of Vitiligo?

Please Click Here to View Support Options



Vitiligo Coping Mechanisms:  
Personality Check

Have you ever admired a person for the strength and grace they seem to have in very difficult situations such as a death in the family? Whether they were born with this ability, learned it from their upbringing, or a combination thereof, the people who handle stress in a more positive manner exhibit certain specific coping mechanisms that are different from those who are more negatively affected by stress.

Research has found the impact of vitiligo on the quality-of-life for those of all ages to be both profound and far-reaching. The manner in which you adapt to vitiligo can affect not only day-to-day decisions such as the type of clothing you wear, or activities in which you might choose not to participate, but can also even affect the progression of the disease.

Because there are no blisters, scales, or rashes, many people deem vitiligo a cosmetic condition. However, if you have vitiligo, you are acutely aware of the less visible, but very significant emotional impact of the disease.

Learning about and identifying your personal stress triggers and coping methods can help you to make adjustments to improve your ability to handle stress, and your overall quality of life.

Quality of Life

Vitiligo not only changes a person’s physical appearance, but many also experience embarrassment, depression, and shame, and refrain from social interaction and events that they once enjoyed. In some areas of the world, vitiligo brings such a stigma as to result in cause for divorce and/or an entire family being shunned in their community.

Times of change, such as meeting new people, going to a new school, or even a weather change requiring a different type of clothing, can all be more emotionally challenging for those with a skin condition.

Children as young as pre-school age express feelings of being different from others and choose not to play in groups with friends where they had once been quite comfortable.

The teen years can also be particularly difficult for those already experiencing physical and hormonal changes while at the same time striving to develop a sense of self-identity. They don’t want to stand out in a crowd for reasons they can’t control.

Many adults describe feeling a loss of identity. Their self-concept and body image no longer resemble the person they see in the mirror. Even those who had been quite successful and confidant can take a significant hit to their self-esteem.

Your attachment style is the way you relate to other people. It affects your feelings of security, the way you build relationships, and even how you parent your children. According to science, these styles are established during the first two years of life, and unless (or until) adjusted, stay with you for life.

Recognizing your personal attachment style can help you understand your emotional limitations as well as changes you can make to improve problem areas

There are Four Attachment Styles, which are based on two factors:
Avoidance and Anxiety

  1. People with a secure attachment style show low avoidance and low anxiety. Low avoidance means that they don’t avoid deep relationships. They are typically happy in their relationships with the people in their lives, and form connections that help in times of need.

  2. People with a preoccupied attachment style show low avoidance and high anxiety. Although they don’t avoid deep relationships, they seek approval and acceptance and can become overly emotional and dependent. They doubt their self-worth and worry about what others think of them
  3. Low Avoidance Example

    When a stranger openly stares or makes a negative comment, some people choose to stare right back, calling out the person directly and telling them to stop. Others prefer to briefly explain what vitiligo is and that it’s not contagious. While these may seem to be different approaches, both are indicative of a low avoidance attachment style, because they are not avoiding the uncomfortable situation.

  4. People with a dismissive-avoidant attachment style show high avoidance and low anxiety. They are self-sufficient and independent, and avoid anxiety by distancing themselves from close emotional relationships.

  5. People with a fearful-avoidant (or anxious avoidant) attachment style show high avoidance and high anxiety, which can stem from childhood trauma or abuse. While these people may desire close relationships, they worry about the intentions of others and many times avoid close relationships to avoid being hurt.

To Take a Quiz to Learn More
about Your Attachment Style:
Click Here

Coping Strategies

The manner in which a person copes with difficult situations is in large part a factor of their attachment style. Some people cope with vitiligo by altering their normal behaviors to avoid situations in which their vitiligo shows, such as swimming or going to the gym. Others try to conceal their vitiligo by wearing extra layers of clothing or applying time-consuming, camouflaging makeup. Understanding the various strategies, identifying how you typically respond, and alternative methods you could try could help improve your coping skills, reduce your level of stress, and improve your overall quality of life.

A study by the University of Sheffield looked at the social anxiety and coping strategies associated with skin conditions like vitiligo. The authors noted that while concealing vitiligo with clothing or makeup might make things easier in the short-term, the restrictions those choices impose on daily life don’t make them a good long-term solution. This study found that the best long-term coping management styles include a variety of behavioral and cognitive strategies combined with social support.

Some people feel as though everyone around them is staring and judging them, which causes them to become hypervigilant and overly focused on the behavior and attention of other people. With modification, instead of automatically assuming that everyone is staring and judging, they can learn ways to more realistically monitor the level of attention from others to determine if people are actually staring, or just momentarily noticing the difference in their skin, which is normal, then moving on.

Another strategy would be to change the way they feel about their vitiligo. This method involves modifying how they personally feel about being different and what they think other people are thinking about them.

Seeking social support from those around you such as your spouse, family members, or friends is most typical among those with low avoidance attachment styles. The reassurance received from others can help encourage you to step out of your comfort zone, leading to healthy behavioral changes such as wearing shorts when it’s hot outside, even if it means your vitiligo will show.

Social support can also help to change the way you conceptualize your vitiligo. For example, if you accept your friends’ invitations to participate in activities with them, you may begin to feel more comfortable in those situations and think more positively about your vitiligo. In time, this could help you feel more secure participating in other social settings.

Cognitive Behavioral Therapy (CBT)

Cognitive behavioral therapy (CBT) is a short-term, goal-oriented, therapy that uses a hands-on approach to improve self-esteem and body image. The goal of CBT is to change the thoughts and behaviors that cause problems in your life. If you automatically have negative thoughts about your vitiligo in certain situations, CBT can help you step outside of these thoughts to take on a more realistic perspective.

Let’s say that when you meet a person for the first time, you automatically think that they’re staring at your vitiligo and hoping that you don’t touch them. Through CBT, you would be encouraged to think back to a real-life experience that triggered those thoughts, then discuss constructive coping mechanisms to find positive ways to handle similar situations in the future.

Self-Help Interventions

Self-help interventions provide patients with a way to receive therapeutic resources and work independently at their own pace. This type of therapy educates the patient about causes of anxiety, and explains methods of cognitive restructuring and relaxation techniques.

The University of Sheffield created a 4 stage self-help guide specifically for those with skin conditions to help them learn to identify their personal stress triggers, and provides techniques to reduce their anxieties.

Stage 1 examines the different ways social anxiety can affect you, such as by avoiding social activities or events, concealing your vitiligo, feeling nervous or embarrassed, experiencing tension and feelings of panic, and assuming you are being judged. These feelings can cause you to focus on yourself and become self-conscious.

Stage 2 helps you learn to monitor the causes of your anxiety so that you can recognize triggers and be prepared to implement self-help techniques. They suggest keeping a log of situations similar to the one below, that make you anxious, and noting your thoughts, emotions, bodily tension, and self-focusing.

Stage 3 introduces two relaxation techniques to reduce self-consciousness when feeling anxious about your vitiligo.

Technique 1 suggests find a relaxing image, such as sitting on a beach by the ocean, and learning to focus on the many sensations you would experience if you were physically there. You progress to a meditation-type exercise, placing yourself in the image. Take deep and even breaths, think of the feelings you associate with that blissful mental image, and allow those relaxed feelings to take over. When you’re done, you assess your level of tension compared to when you began the exercise. 

Technique 2 begins with a similar meditative relaxation technique. This exercise teaches you how to focus all of your attention on something very specific, such as a clock ticking, and tuning out everything else. Then you switch your attention to something different, such as the hum of a computer, and tune out all else, including the previous sound of your focus. This exercise helps you learn to turn your attention away from your skin in uncomfortable situations.

Stage 4 helps you identify specific situations that trigger anxiety, choose an appropriate relaxation technique, and discusses ways to implement.

This section provides two “if-then” charts
based on the above relaxation techniques

To Read the Complete Self-Help Guide: Click here

Whether you are young or old, recently diagnosed with vitiligo, or have had it for many years, the uncertainties of living with a progressive, disfiguring skin disease can, at the very least, lead to increased levels of stress and anxiety. If not addressed, the impact can significantly affect your sense of well-being, both short-term and long.

Emotional stress is a documented trigger for onset, or worsening of, many autoimmune diseases, including vitiligo. Learning to identify your personal stress triggers, why you react a certain way in difficult situations, and how to make positive changes, can not only help you live a happier and more productive life, but may also help to stabilize your vitiligo.

Those who were born with a secure attachment style and have a strong social network are more likely to adjust more easily than those with a high anxiety attachment style and weak social network. However, with time and practice, even those with a less secure attachment style can learn effective coping mechanisms to help modify pre-existing behaviors, gain confidence, and improve their overall quality of life.


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Camp Discovery 2017!

The American Academy of Dermatology’s (AAD) Camp Discovery program is for children ages 8-16 who have a chronic skin disease. Under the expert care of dermatologists and nurses, Camp Discovery gives campers the opportunity to spend a week with other young people with skin conditions having fun and participating in activities such as swimming, horseback riding, arts and crafts and many more. There is no fee to attend, all costs including transportation, are provided by the AAD through generous donations from its members, outside organizations and individuals.

  • All children must be referred by their dermatologist. Parents can copy the Camper Referral form and take it to their dermatologist.

  • Volunteer Applicants must be at least 18 years of age and provide one letter of recommendation.   
    Click Here for Volunteer Application

  • There is no fee to attend, all costs including transportation, are provided by the AAD through generous donations from its members, outside organizations and individuals.

Click on the dates below for each camp for specific information about that camp.

June 18 – 23: Crosslake, Minnesota (ages 8 -13)
July 2 - 7: Crosslake, Minnesota (ages 14 -16)
August 6 - 11: Burton, Texas (ages 8 -16)
August 12 - 18: Millville, Pennsylvania (ages 8 -16)
August 13 - 19: Andover, Connecticut (ages 8 -16)

For more information about attending or volunteering:

Visit, or

Contact Janine Mueller at 847-240-1737, or [email protected]



Calling all Medicare Vitiligo Patients!

VSIVSI regularly hears from patients from all over the United States who have been denied insurance coverage for their vitiligo treatment. VSI has been fighting this battle on a national level for several years. While we are definitely making progress, it’s been a slow road.

Part of the problem is that currently there is no accepted standard for coverage of vitiligo treatments. Each company has their own policies and guidelines, many times based on outdated and incorrect information.

What most people may not realize is just how much private insurance coverage can be affected by Medicare policies. Over 55 million Americans are now covered by Medicare or Medicare Advantage, making it the nation’s largest health insurance program. Consequently, many, if not most, insurance providers establish their baseline standards and procedures to follow the Medicare model.

We have been in touch with Medicare and have been told that if we can provide a Medicare letter of denial for a vitiligo treatment, then they will try to help us set a standard of coverage.

If you are reading this newsletter and you, or someone you know, was denied coverage for a vitiligo treatment by Medicare, please contact VSI immediately. You could help make a difference for future insurance coverage for ALL vitiligo patients! Click Here to Contact VSI




What's On Your Mind?

Q. I have been using a topical ointment twice a day for nearly three months and am worried that it is not working. I have not seen any improvement where I am applying the ointment, and I now seem to be losing pigment in other areas. What should I do?VSI

  1. The first thing to remember is that vitiligo treatments take time. Even when using twice a day, when a topical is used alone (not combined with phototherapy) it can take 6 months before you begin to see results.

    Also, a topical repigmentation treatment can only treat the area to which it is applied. It cannot stop new lesions from forming. If the vitiligo is spreading quickly, with a fair amount of pigment loss, it may be necessary to use some type of systemic treatment to stabilize the vitiligo. Some doctors prescribe a corticosteroid (either oral or injection) to help stabilize. Full body light treatment can also suppress the immune response and stabilize vitiligo.

    If your vitiligo has been stable for a while and you suddenly begin losing pigment, it might also be a good idea to ask your doctor about testing for underlying conditions that may be contributing to the vitiligo activity. Some underlying conditions frequently seen with vitiligo are autoimmune thyroid disease, type 1 diabetes, rheumatoid arthritis, celiac disease, and vitamin D deficiency.

For additional information on vitiligo and thyroid disease,
and diagnostic tests for vitiligo: Click Here

Q. How long should I continue treating an area that has repigmented?VSI

  1. If the new pigment has completely filled in the area, but is a bit lighter in color, this is called trichrome vitiligo and is considered to be a stage of active vitiligo. Once the new pigment matches the surrounding skin, it’s a good idea to continue treating the area for a few more weeks to be sure it is stable.


    French researchers noted that continuous low-level use of topical corticosteroids and calcineurin inhibitors (such as tacrolimus) can prevent new flares of atopic dermatitis. Because the risk of relapse of repigmentation in vitiligo can be as high as 40% within the first year, in 2014, the French researchers carried out a study to determine if a similar protocol might help maintain vitiligo repigmentation.

    All participants began the maintenance program within 2 weeks of full repigmentation and continued for 24 weeks. One group applied 0.1% tacrolimus to the newly-repigmented areas twice a week on non-consecutive days, and the other group applied a placebo ointment on the same schedule.

    This study found the twice weekly application of tacrolimus ointment to be an effective maintenance therapy, with a much lower re-depigmentation rate.


Medical News Updates

Highlights of recently-published medical
articles on vitiligo and its treatments

A Test to Predict Onset or Worsening of Vitiligo!

Unlike many inflammatory skin conditions that begin with redness, bumps, or rashes, by the time vitiligo becomes apparent, disease progression has likely been underway for several months.

Tests that could confirm active disease prior to visible signs, as well as predict the likelihood of future disease progression, would allow for an earlier start of treatment and better management of the disease.

A recent study conducted at the Ghent University Hospital Department of Dermatology, in Ghent, Belgium looked at two specific biomarkers associated with other autoimmune disorders connected to vitiligo to determine if they could help predict vitiligo activity and progression:

Soluble CD27 (sCD27) is a protein associated with immune system cells, including the T-cells that target the melanocytes in those with vitiligo. Blood levels of sCD27 have been shown to be elevated in systemic lupus erythematosus and celiac disease, both of which are also associated with vitiligo.

Soluble CD25 (sCD25) is another protein important in T-cell development

The study looked at 93 patients with vitiligo who were either not treating their vitiligo or were using topical therapies such as corticosteroids, tacrolimus, and/or pimecrolimus.

Each participant completed a survey to describe whether their vitiligo was active (spreading), stable (no activity), or repigmenting, during the previous 3, 6, or 12 months.

After looking at the surveys and examining the patients, the doctors placed the participants into one of three categories:

  1. Active (worsening of pigment loss)
  2. Stable (no pigment loss activity)
  3. Repigmenting

Blood levels were tested for the sCD27 and sCD25 biomarkers.
Below are the testing results:  

The discovery of these findings is very encouraging and the biomarker research continues with the hope of providing better diagnostic and treatment tools for the future.



Another Drug Shows Promise for Vitiligo
Clinical Trial Soon to Begin Recruiting

Last year VSI reported on a drug in the news called tofacitinib (Xeljanz) that provided very remarkable repigmentation in a case study. This medication, known as a janus kinase (JAK) inhibitor, works by inhibiting the activity of the signaling pathways that cause or trigger certain diseases.

Researchers have for several years been closing in on the biological pathways that could turn off the immune response that causes vitiligo. However, as previously noted, caution must be exercised when turning off vitiligo’s immune response to melanocytes due to the risk of removing the body’s ability to recognize the cells that cause melanoma, which from a health standpoint would be a far worse diagnosis.

The good news is, vitiligo research is moving at a record pace, and researchers are zeroing in on the specific pathways involved with vitiligo, as well as the drugs that target those specific signals. By using a targeted treatment rather than turning off the entire immune system, which can have significant side effects, the treatment targets only very specific areas (or pathways), leaving the rest of the immune system alone to do its job.

Ruxolitinib (Jakafi), another JAK inhibitor already on the market for other conditions, has been studied in a topical cream for psoriasis and rheumatoid arthritis, showing positive results with very few (mild) side effects.

In 2016, Dr. John Harris (University of Massachusetts Medical School, Department of Dermatology), reported a case study of a patient he was treating for alopecia areata (AA), who also happened to have vitiligo. This patient was treating with ruxolitinib 20 mg orally twice a day for twenty weeks.

After 4 weeks, his AA began responding to the treatment, and after 12 weeks, he began regaining pigment on his face. At the conclusion of the study (20 weeks), he had regained 51% of his facial pigmentation, compared to only 8% when the study began.

At a 12 week follow-up visit, while he maintained his hair regrowth, he had unfortunately lost quite a bit of his new pigment.

In June 2016, Tufts Medical Center conducted an Open Label Phase 2 Proof-of-Concept Pilot Trial for vitiligo, using a topical form of ruxolitinib. This is significant, because topical medications can be applied directly to the affected areas, reducing the overall systemic absorption and side-effects. This type of treatment could potentially be used for a longer period of time, producing more sustainable results.

Sign up for Ruxolitinib Clinical Trial!

Another vitiligo study with topical ruxolitinib is scheduled to begin in the coming weeks and will be recruiting participants. VSI will make the information available once it has been released. Keep an eye on both our Community Page News and Updates and on our Facebook Page 

 To see previous article on Tofacitinib: Click Here


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Research & Clinical Trials

Online Vitiligo "Selfie" Study!

Vitiligo Selfie Study

Research Coordinator: Elizabeth Tkachenko

Online Study Conducted by:

University of Massachusetts Medical School
Department of Dermatology

The goal of this study is to observe how vitiligo changes, moves, or resolves over time using self-taken, “selfie” photographs.

If you choose to participate, you will send us one photo per week for 52 weeks (one year). By combining and tracking these photos, we will be able to determine how the lesions in vitiligo tend to change and progress over time.

The entire study will take place online, and you will receive weekly email reminders containing a direct link to the short survey and secure photo-upload feature.

We are looking for participants with darker skin tones who are currently not receiving any treatment for their vitiligo.

If you are interested in participating, please contact research staff and we can send more information, answer your questions, and determine if you are eligible to participate in the study. Contact: [email protected]

Vitiligo Research Study in New York City.

Volunteers Wanted

Have you been diagnosed with vitiligo?

Would you like to take part in a research study
to help those who have been diagnosed?

We are looking for both healthy volunteers and persons diagnosed with vitiligo to take part in a research study.

We are recruiting from the NYC areas since volunteers must visit our clinic on two separate occasions.

The biology of vitiligo is poorly understood and while there are many treatment options, many carry the risk of side effects or are only temporarily effective. We are performing a study to improve our understanding of the biology of vitiligo. Subjects will be asked to come to 2 study visits.  We will be collecting skin samples from both patients diagnosed with vitiligo as well as healthy adults for this study.

We will compare pigment cells from the two groups to identify differences that may contribute to progression of vitiligo. This is not a treatment trial. This information may allow us to develop improved treatments for vitiligo.

Study visits will take place at:

The Dermatology Clinical Studies Unit
NYULMC Ambulatory Care Center
240 East 38th Street, 11th Floor
New York, NY 10016

For more information, please contact:
[email protected]

IRB Approved For Period 10/4/16 – 10/3/17


NEW! - Support VSI Through Ebay


New Way To Support VSI Through Ebay!

Do you sell items on eBay, or want to hold an online garage sale? If so, consider donating a percentage of your proceeds to VSI through eBay’s Giving Works program! It’s easy – when you list an item through a Giving Works listing, choose to send 10-100% of the final sale price to VSI. Your listing will have a special placement and designation. You’ll receive a proportional fee credit from eBay, and will also receive a tax donation receipt when the donation is deducted from your funds received. It’s a great opportunity to make some money for yourself and for VSI, so clean out those closets and garages and get selling! 

To Learn More About VSI's Giving Works: Click here


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Your Online Shopping Can Benefit VSI!

Tobi Cares Donation Program

Tobi is an online women's clothing design label that brings LA style from its design studio direct to its online clothing store at  Go to Tobi Cares and sign up for VSI to receive 1% of your purchase amount.


With thousands of items in addition to books, is a one stop-shopping center! Simply shop through the above link (bookmark it for easy reference) and VSI will earn fees, based on a percentage of the sale. The more items purchased by members, the higher the percentage! Our Vitiligo Library and Store, containing books, articles and products for those with vitiligo, is also powered by Amazon.

iGIVE SHOPPING offers access to free shipping deals and exclusive coupons, on top of the great deals you'll find every day through its network of 1,000+ stores, including Pottery Barn, REI, Staples, Petco, Expedia, Best Buy, QVC and many more. Best of all, up to 26% of your purchase at each store is donated to VSI at no cost to you! Let friends and family know so they can support VSI, too. Click register for iGive to get started today, and download the iGive button to automatically benefit VSI whenever you go to an included store. You can also raise a penny per search through iGive’s search engine,


GoodSearch and Goodshop, like iGive, offers coupons, discounts, and donations to VSI through its network of over 5,000 stores. Just click the link above to get the savings started and the donations flowing!

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